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TNFSF13B Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y275 |
|---|---|
| Clone Names | 100427269 |
| Gene ID | 10673 |
|---|---|
| Other Names | Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13996a was selected from the N-term region of TNFSF13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF13B |
|---|---|
| Synonyms | BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thiscytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA,and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineagecells, and acts as a potent B cell activator. It has been alsoshown to play an important role in the proliferation anddifferentiation of B cells.
References
Zhang, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18956-18960(2010)Molica, S., et al. Eur. J. Haematol. 85(4):314-320(2010)Liu, J.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(3):690-693(2010)Onda, K., et al. Int. J. Hematol. 91(5):808-819(2010)Hayashi, E.A., et al. J. Immunol. 184(9):4662-4672(2010)
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