GTF2H1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P32780 |
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Clone Names | 100430087 |
Gene ID | 2965 |
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Other Names | General transcription factor IIH subunit 1, Basic transcription factor 2 62 kDa subunit, BTF2 p62, General transcription factor IIH polypeptide 1, TFIIH basal transcription factor complex p62 subunit, GTF2H1, BTF2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GTF2H1 |
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Synonyms | BTF2 |
Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Wu, W., et al. Lung Cancer 63(2):180-186(2009)Bethke, L., et al. J. Natl. Cancer Inst. 100(4):270-276(2008)Di Lello, P., et al. Biochemistry 44(21):7678-7686(2005)
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