SMO Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99835 |
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Clone Names | 100430130 |
Gene ID | 6608 |
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Other Names | Smoothened homolog, SMO, Protein Gx, SMO, SMOH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SMO |
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Synonyms | SMOH |
Function | G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein. Cell projection, cilium. Note=Cilium localization is promoted by SHH and is required for activity. {ECO:0000250|UniProtKB:P56726} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a G protein-coupledreceptor that interacts with the patched protein, a receptor forhedgehog proteins. The encoded protein tranduces signals to otherproteins after activation by a hedgehog protein/patched proteincomplex.
References
Zhang, L., et al. Oral Dis 16(8):818-822(2010)Desch, P., et al. Oncogene 29(35):4885-4895(2010)Walter, K., et al. Clin. Cancer Res. 16(6):1781-1789(2010)Hirotsu, M., et al. Mol. Cancer 9, 5 (2010) :Rittie, L., et al. Aging Cell 8(6):738-751(2009)
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