AKR1D1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51857 |
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Clone Names | 110617053 |
Gene ID | 6718 |
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Other Names | 3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AKR1D1 |
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Synonyms | SRD5B1 |
Function | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in liver. Expressed in testis and weakly in colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene is responsible for thecatalysis of the 5-beta-reduction of bile acid intermediates andsteroid hormones carrying a delta(4)-3-one structure. Deficiency ofthis enzyme may contribute to hepatic dysfunction. Three transcriptvariants encoding different isoforms have been found for this gene.Other variants may be present, but their full-length natures havenot been determined yet.
References
Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)
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