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SEPP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P49908 |
|---|---|
| Clone Names | 100623043 |
| Gene ID | 6414 |
|---|---|
| Other Names | Selenoprotein P, SeP, SEPP1, SELP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SELENOP {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:10751} |
|---|---|
| Function | Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. |
| Cellular Location | Secreted. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250|UniProtKB:P70274} |
| Tissue Location | Made in the liver and heart and secreted into the plasma. It is also found in the kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a selenoprotein containing multipleselenocysteine (Sec) residues, which are encoded by the UGA codonthat normally signals translation termination. The 3' UTR ofselenoprotein genes have a common stem-loop structure, the secinsertion sequence (SECIS), which is necessary for the recognitionof UGA as a Sec codon rather than as a stop signal. Thisselenoprotein is an extracellular glycoprotein, and is unusual inthat it contains 10 Sec residues per polypeptide. It is aheparin-binding protein that appears to be associated withendothelial cells, and has been implicated to function as anantioxidant in the extracellular space. Several transcriptvariants, encoding either the same or different isoform, have beenfound for this gene.
References
Sun, W., et al. Br. J. Nutr. 104(9):1283-1287(2010)Roman, M., et al. Transl Res 156(4):242-250(2010)Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Takemoto, A.S., et al. Ethn Dis 20 (1 SUPPL 1), S1-S925 (2010) :
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