SNRNP70 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P08621 |
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Clone Names | 100617262 |
Gene ID | 6625 |
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Other Names | U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70, SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SNRNP70 |
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Synonyms | RNPU1Z, RPU1, SNRP70, U1AP1 |
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). |
Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376} |
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Provided below are standard protocols that you may find useful for product applications.
Background
SNRNP70 mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
References
Spiluttini, B., et al. J. Cell. Sci. 123 (PT 12), 2085-2093 (2010) :Tzang, B.S., et al. J. Biomed. Sci. 17, 40 (2010) :Parente Costa, L., et al. J. Autoimmun. 33(2):121-124(2009)Hernandez, H., et al. PLoS ONE 4 (9), E7202 (2009) :Palafox Sanchez, C.A., et al. Arthritis Res. Ther. 11 (1), R27 (2009) :
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