CRLF1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75462 |
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Clone Names | 110617021 |
Gene ID | 9244 |
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Other Names | Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CRLF1 |
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Function | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. |
Cellular Location | Secreted. |
Tissue Location | Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cytokine type I receptorfamily. The protein forms a secreted complex withcardiotrophin-like cytokine factor 1 and acts on cells expressingciliary neurotrophic factor receptors. The complex can promotesurvival of neuronal cells. Mutations in this gene result inCrisponi syndrome and cold-induced sweating syndrome. [provided byRefSeq].
References
Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)
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