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CACNB3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P54284 |
|---|---|
| Clone Names | 100712280 |
| Gene ID | 784 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3, CACNB3, CACNLB3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CACNB3 |
|---|---|
| Synonyms | CACNLB3 {ECO:0000303|PubMed:7557998} |
| Function | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed mostly in brain, colon and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
References
Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)Bernardo, J.F., et al. Can. J. Physiol. Pharmacol. 87(7):522-530(2009)Voss, M., et al. BMC Immunol. 10, 53 (2009) :Rikova, K., et al. Cell 131(6):1190-1203(2007)Vendel, A.C., et al. J. Neurosci. 26(10):2635-2644(2006)
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