FNDC4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H6D8 |
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Clone Names | 110811078 |
Gene ID | 64838 |
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Other Names | Fibronectin type III domain-containing protein 4, Fibronectin type III repeat-containing protein 1, FNDC4, FRCP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FNDC4 |
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Synonyms | FRCP1 |
Function | Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. |
Cellular Location | Membrane; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:Q3TR08}. Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein {ECO:0000250|UniProtKB:Q3TR08} |
Tissue Location | Up-regulated in colon cells of patients with inflammatory bowel disease (IBD). |
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Provided below are standard protocols that you may find useful for product applications.
Background
FNDC4 contains a fibronectin type-III (FN3) domain. FN3 repeats have been found in various protein families including extracellular-matrix molecules, cell-surface receptors, enzymes, and muscle proteins. The function of FNDC4 is unknown.
References
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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