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GALNT13 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IUC8 |
|---|---|
| Clone Names | 100405070 |
| Gene ID | 114805 |
|---|---|
| Other Names | Polypeptide N-acetylgalactosaminyltransferase 13, Polypeptide GalNAc transferase 13, GalNAc-T13, pp-GaNTase 13, Protein-UDP acetylgalactosaminyltransferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, GALNT13, KIAA1918 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GALNT13 |
|---|---|
| Synonyms | KIAA1918 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:22186971). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O- glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:12407114, PubMed:22186971) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Specifically expressed in neuronal cells. Expressed in fetal brain, whole adult brain, cerebral cortex and cerebellum. Not expressed in other tissues tested. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The GALNT13 protein is a member of theUDP-N-acetyl-alpha-D-galactosamine:polypeptideN-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family,which initiate O-linked glycosylation of mucins (see MUC3A, MIM158371) by the initial transfer of N-acetylgalactosamine (GalNAc)with an alpha-linkage to a serine or threonine residue.[supplied byOMIM].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ng, D., et al. Int. J. Cancer 123(7):1610-1615(2008)Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :Hillier, L.W., et al. Nature 434(7034):724-731(2005)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
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