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RAB4B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P61018 |
|---|---|
| Clone Names | 100416295 |
| Gene ID | 53916 |
|---|---|
| Other Names | Ras-related protein Rab-4B, RAB4B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAB4B (HGNC:9782) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
RAB proteins, such as RAB4B, are members of the RASsuperfamily of small GTPases that are involved in vesiculartrafficking (He et al., 2002 [PubMed 12450215]).
References
Kaddai, V., et al. PLoS ONE 4 (4), E5257 (2009) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)He, H., et al. Gene Expr. 10 (5-6), 231-242 (2002) :
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