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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SPAM1 Antibody (C-term) Blocking Peptide   

SPAM1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P38567
Clone Names 100324159
Additional Information
Gene ID 6677
Other Names Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20, SPAM1, HYAL3, PH20
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPAM1
Synonyms HYAL3, PH20
Function Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location Testis..
Research Areas
Citations (0)

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Hyaluronidase degrades hyaluronic acid, a major structuralproteoglycan found in extracellular matrices and basementmembranes. Six members of the hyaluronidase family are clusteredinto two tightly linked groups on chromosome 3p21.3 and 7q31.3.This gene was previously referred to as HYAL1 and HYA1 and hassince been assigned the official symbol SPAM1; another familymember on chromosome 3p21.3 has been assigned HYAL1. This geneencodes a GPI-anchored enzyme located on the human sperm surfaceand inner acrosomal membrane. This multifunctional protein is ahyaluronidase that enables sperm to penetrate through thehyaluronic acid-rich cumulus cell layer surrounding the oocyte, areceptor that plays a role in hyaluronic acid induced cellsignaling, and a receptor that is involved in sperm-zona pellucidaadhesion. Abnormal expression of this gene in tumors has implicatedthis protein in degradation of basement membranes leading to tumorinvasion and metastasis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].


Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Dunn, C.A., et al. BMC Genomics 6 (1), 47 (2005) :Evans, E.A., et al. Reprod. Biol. Endocrinol. 1, 54 (2003) :Cherr, G.N., et al. Matrix Biol. 20(8):515-525(2001)Csoka, A.B., et al. Matrix Biol. 20(8):499-508(2001)

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$ 277.78
Cat# BP19001b
Availability: 2 weeks
Bulk Size

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