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SYT1 Antibody (Center K237) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P21579
Clone Names 111205012
Additional Information
Gene ID 6857
Other Names Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT1
Synonyms SVP65, SYT
Function Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}
Tissue Location Expressed in melanocytes (PubMed:23999003).
Research Areas
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Background

The synaptotagmins are integral membrane proteins ofsynaptic vesicles thought to serve as Ca(2+) sensors in the processof vesicular trafficking and exocytosis. Calcium binding tosynaptotagmin-1 participates in triggering neurotransmitter releaseat the synapse (Fernandez-Chacon et al., 2001 [PubMed11242035]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (2), G203-G211 (2010) :Kathir, K.M., et al. Biochim. Biophys. Acta 1798(2):297-302(2010)Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)

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$ 277.78
Cat# BP19117c
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