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Mouse Cbx5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q61686 |
|---|---|
| Clone Names | 110919055 |
| Gene ID | 12419 |
|---|---|
| Other Names | Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Cbx5 |
|---|---|
| Synonyms | Hp1a |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P45973}. Chromosome {ECO:0000250|UniProtKB:P45973}. Chromosome, centromere {ECO:0000250|UniProtKB:P45973}. Note=Colocalizes with HNRNPU in the nucleus (By similarity). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:P45973} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).
References
Sun, Y., et al. Biophys. J. 99(4):1274-1283(2010)Muller, K.P., et al. Biophys. J. 97(11):2876-2885(2009)Dong, K.B., et al. EMBO J. 27(20):2691-2701(2008)Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(26):9047-9052(2008)Brancorsini, S., et al. Cell Cycle 7(10):1415-1422(2008)
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