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Mouse Cbx5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q61686
Clone Names 110919055
Additional Information
Gene ID 12419
Other Names Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cbx5
Synonyms Hp1a
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P45973}. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (By similarity). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase {ECO:0000250|UniProtKB:P45973}
Research Areas
Citations (0)

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Background

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).

References

Sun, Y., et al. Biophys. J. 99(4):1274-1283(2010)Muller, K.P., et al. Biophys. J. 97(11):2876-2885(2009)Dong, K.B., et al. EMBO J. 27(20):2691-2701(2008)Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(26):9047-9052(2008)Brancorsini, S., et al. Cell Cycle 7(10):1415-1422(2008)

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$ 277.78
Cat# BP19229b
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