|Other Names||Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein with twoextracellular Kunitz domains that inhibits a variety of serineproteases. The protein inhibits HGF activator which prevents theformation of active hepatocyte growth factor. This gene is aputative tumor suppressor, and mutations in this gene result incongenital sodium diarrhea. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Dong, W., et al. Int. J. Cancer 127(7):1526-1534(2010)Bergum, C., et al. Prostate 70(13):1422-1428(2010)Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :Yamauchi, M., et al. Biol. Chem. 383(12):1953-1957(2002)Itoh, H., et al. Eur. J. Biochem. 267(11):3351-3359(2000)
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