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SPINT2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O43291
Clone Names 100525217
Additional Information
Gene ID 10653
Other Names Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPINT2
Synonyms HAI2, KOP
Function Inhibitor of HGFAC (PubMed:9346890). Also inhibits plasmin, and plasma and tissue kallikrein (PubMed:9115294). Inhibits serine protease activity of TMPRSS13 (PubMed:20977675, PubMed:28710277). Inhibits serine protease activity of ST14/matriptase in vitro (PubMed:28710277).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm
Tissue Location Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
Research Areas
Citations (0)
citation

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Background

This gene encodes a transmembrane protein with twoextracellular Kunitz domains that inhibits a variety of serineproteases. The protein inhibits HGF activator which prevents theformation of active hepatocyte growth factor. This gene is aputative tumor suppressor, and mutations in this gene result incongenital sodium diarrhea. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

References

Dong, W., et al. Int. J. Cancer 127(7):1526-1534(2010)Bergum, C., et al. Prostate 70(13):1422-1428(2010)Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :Yamauchi, M., et al. Biol. Chem. 383(12):1953-1957(2002)Itoh, H., et al. Eur. J. Biochem. 267(11):3351-3359(2000)

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$ 277.78
Cat# BP19268b
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