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DLK Antibody (C-term D842) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q12852
Clone Names 2031102
Additional Information
Gene ID 7786
Other Names Mitogen-activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, MAP3K12, ZPK
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K12
Synonyms ZPK
Function Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q60700}. Cell membrane {ECO:0000250|UniProtKB:Q60700}. Note=Behaves essentially as an integral membrane protein. {ECO:0000250|UniProtKB:Q60700}
Tissue Location Highly expressed in brain and kidney.
Research Areas
Citations (0)

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This gene encodes a member of the serine/threonine proteinkinase family. This kinase contains a leucine-zipper domain and ispredominately expressed in neuronal cells. The phosphorylationstate of this kinase in synaptic terminals was shown to beregulated by membrane depolarization via calcineurin. This kinaseforms heterodimers with leucine zipper containing transcriptionfactors, such as cAMP responsive element binding protein (CREB) andMYC, and thus may play a regulatory role in PKA or retinoic acidinduced neuronal differentiation. Alternatively spliced transcriptvariants encoding different proteins have been described.[providedby RefSeq].


Clague, J., et al. Mol. Carcinog. 49(2):183-189(2010)Robitaille, H., et al. J. Invest. Dermatol. 130(1):74-85(2010)Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Daviau, A., et al. Cell. Signal. 21(4):577-587(2009)Mukhopadhyay, R., et al. Mol. Cell 32(3):371-382(2008)

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$ 277.78
Cat# BP19279b
Availability: 2 weeks
Bulk Size

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