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VPREB1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12018 |
|---|---|
| Clone Names | 110901249 |
| Gene ID | 7441 |
|---|---|
| Other Names | Immunoglobulin iota chain, CD179 antigen-like family member A, Protein VPreB1, V(pre)B protein, VpreB protein, CD179a, VPREB1, VPREB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | VPREB1 |
|---|---|
| Synonyms | VPREB |
| Function | Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B- cell differentiation. |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:P13372} |
| Tissue Location | Only expressed by pre-B-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to theimmunoglobulin superfamily and is expressed selectively at theearly stages of B cell development, namely, in proB and early preBcells. This gene encodes the iota polypeptide chain that isassociated with the Ig-mu chain to form a molecular complex whichis expressed on the surface of pre-B cells. The complex is thoughtto regulate Ig gene rearrangements in the early steps of B-celldifferentiation.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Rossi, B., et al. J. Immunol. 177(2):796-803(2006)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Gauthier, L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(20):13014-13019(2002)
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