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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Lgals3 Antibody (Center) Blocking Peptide   

Mouse Lgals3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P16110
Clone Names 110919068
Additional Information
Other Names Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, IgE-binding protein, L-34 galactoside-binding lectin, Laminin-binding protein, Lectin L-29, Mac-2 antigen, Lgals3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lgals3
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P17931}. Nucleus {ECO:0000250|UniProtKB:P17931}. Secreted {ECO:0000250|UniProtKB:P17931}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P17931}
Tissue Location The highest levels are found in activated macrophages EMBL; X16834; CAA34736.1; -; mRNA EMBL; J03723; AAA37311.1; -; mRNA EMBL; X16074; CAA34206.1; -; mRNA CCDS; CCDS26986.1; - PIR; S08537; A28651 SMR; P16110; - DIP; DIP-2152N; - IntAct; P16110; 6 STRING; 10090.ENSMUSP00000114350; - BindingDB; P16110; - ChEMBL; CHEMBL3668; - iPTMnet; P16110; - PhosphoSitePlus; P16110; - SwissPalm; P16110; - EPD; P16110; - jPOST; P16110; - MaxQB; P16110; - PaxDb; P16110; - PeptideAtlas; P16110; - PRIDE; P16110; - MGI; MGI:96778; Lgals3 eggNOG; KOG3587; Eukaryota InParanoid; P16110; - Reactome; R-MMU-6798695; Neutrophil degranulation ChiTaRS; Lgals3; mouse PRO; PR:P16110; - Proteomes; UP000000589; Unplaced RNAct; P16110; protein GO; GO:0009986; C:cell surface; IDA:CACAO GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL GO; GO:0005737; C:cytoplasm; IDA:MGI GO; GO:0009897; C:external side of plasma membrane; IDA:MGI GO; GO:0031012; C:extracellular matrix; IDA:MGI GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005615; C:extracellular space; HDA:BHF-UCL GO; GO:0097386; C:glial cell projection; IDA:MGI GO; GO:0001772; C:immunological synapse; IDA:BHF-UCL GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0044216; C:other organism cell; ISO:MGI GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW GO; GO:0050785; F:advanced glycation end-product receptor activity; ISO:MGI GO; GO:0042056; F:chemoattractant activity; ISO:MGI GO; GO:0048030; F:disaccharide binding; ISO:MGI GO; GO:0034988; F:Fc-gamma receptor I complex binding; ISO:MGI GO; GO:0019863; F:IgE binding; ISO:MGI GO; GO:0043236; F:laminin binding; ISO:MGI GO; GO:0048029; F:monosaccharide binding; ISO:MGI GO; GO:0070492; F:oligosaccharide binding; ISO:MGI GO; GO:0019903; F:protein phosphatase binding; ISO:MGI GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0048245; P:eosinophil chemotaxis; ISO:MGI GO; GO:0030198; P:extracellular matrix organization; IGI:MGI GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO; GO:0031640; P:killing of cells of other organism; ISO:MGI GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI GO; GO:0002548; P:monocyte chemotaxis; ISO:MGI GO; GO:0071674; P:mononuclear cell migration; ISO:MGI GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI GO; GO:1903769; P:negative regulation of cell proliferation in bone marrow; ISO:MGI GO; GO:0045806; P:negative regulation of endocytosis; IMP:BHF-UCL GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:MGI GO; GO:2000521; P:negative regulation of immunological synapse formation; IMP:BHF-UCL GO; GO:2001189; P:negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IMP:BHF-UCL GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:BHF-UCL GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI GO; GO:0050918; P:positive chemotaxis; ISO:MGI GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI GO; GO:0071677; P:positive regulation of mononuclear cell migration; ISO:MGI GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISO:MGI GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI GO; GO:0014064; P:positive regulation of serotonin secretion; ISO:MGI GO; GO:1902041; P:regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:MGI GO; GO:0070232; P:regulation of T cell apoptotic process; ISO:MGI GO; GO:0042129; P:regulation of T cell proliferation; ISO:MGI GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW GO; GO:0001501; P:skeletal system development; IGI:MGI CDD; cd00070; GLECT; 1 InterPro; IPR013320; ConA-like_dom_sf InterPro; IPR015534; Galectin_3 InterPro; IPR001079; Galectin_CRD PANTHER; PTHR11346:SF26; PTHR11346:SF26; 1 Pfam; PF00337; Gal-bind_lectin; 1 SMART; SM00908; Gal-bind_lectin; 1 SMART; SM00276; GLECT; 1 SUPFAM; SSF49899; SSF49899; 1 PROSITE; PS51304; GALECTIN; 1 1: Evidence at protein level; Acetylation; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome INIT_MET 1 /note="Removed" /evidence="ECO:0000250|UniProtKB:P38486" CHAIN 2..264 /note="Galectin-3" /id="PRO_0000076931" REPEAT 35..43 /note="1" REPEAT 44..52 /note="2" REPEAT 53..61 /note="3" REPEAT 62..70 /note="4" REPEAT 71..79 /note="5" REPEAT 80..88 /note="6" REPEAT 89..97 /note="7" REPEAT 98..107 /note="8" REPEAT 108..114 /note="9; truncated" DOMAIN 132..262 /note="Galectin" /evidence="ECO:0000255|PROSITE-ProRule:PRU00639" REGION 35..114 /note="9 X 9 AA tandem repeats of Y-P-G-X(3)-P-[GS]-A" REGION 195..201 /note="Beta-galactoside binding" /evidence="ECO:0000250" MOTIF 240..255 /note="Nuclear export signal" MOD_RES 2 /note="N-acetylalanine" /evidence="ECO:0000250|UniProtKB:P38486" MOD_RES 6 /note="Phosphoserine; by CK1" /evidence="ECO:0000250|UniProtKB:P38486" MOD_RES 202 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:P17931" DISULFID 187 /note="Interchain" /evidence="ECO:0000269|PubMed:1917966" CONFLICT 2 /note="A -> R (in Ref. 2; AAA37311)" /evidence="ECO:0000305" CONFLICT 4 /note="S -> T (in Ref. 3; CAA34206)" /evidence="ECO:0000305" CONFLICT 92..93 /note="QP -> ST (in Ref. 3; CAA34206)" /evidence="ECO:0000305" CONFLICT 110..112 /note="QCS -> SAP (in Ref. 3; CAA34206)" /evidence="ECO:0000305" CONFLICT 252 /note="G -> R (in Ref. 2; AAA37311)" /evidence="ECO:0000305" SEQUENCE 264 AA; 27515 MW; 1B5A8A81093D68F6 CRC64; MADSFSLNDA LAGSGNPNPQ GYPGAWGNQP GAGGYPGAAY PGAYPGQAPP GAYPGQAPPG AYPGQAPPSA YPGPTAPGAY PGPTAPGAYP GQPAPGAFPG QPGAPGAYPQ CSGGYPAAGP YGVPAGPLTV PYDLPLPGGV MPRMLITIMG TVKPNANRIV LDFRRGNDVA FHFNPRFNEN NRRVIVCNTK QDNNWGKEER QSAFPFESGK PFKIQVLVEA DHFKVAVNDA HLLQYNHRMK NLREISQLGI SGDITLTSAN HAMI
Research Areas
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Background

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity).

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$ 277.78
Cat# BP19314c
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