PASD1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IV76 |
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Clone Names | 90625162 |
Gene ID | 139135 |
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Other Names | PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PASD1 (HGNC:20686) |
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Function | Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). |
Cellular Location | [Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801) |
Tissue Location | Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151) Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is thought to function asa transcription factor. The protein is a cancer-associated antigenthat can stimulate autologous T-cell responses, and it is thereforeconsidered to be a potential immunotherapeutic target for thetreatment of various hematopoietic malignancies, including diffuselarge B-cell lymphoma.
References
Ghafouri-Fard, S., et al. Br. J. Dermatol. 162(4):772-779(2010)Ait-Tahar, K., et al. Br. J. Haematol. 146(4):396-407(2009)Sahota, S.S., et al. Blood 108(12):3953-3955(2006)Cooper, C.D., et al. Leukemia 20(12):2172-2174(2006)Guinn, B.A., et al. Biochem. Biophys. Res. Commun. 335(4):1293-1304(2005)
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