|Other Names||PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).|
|Cellular Location||[Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801)|
|Tissue Location||Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151) Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is thought to function asa transcription factor. The protein is a cancer-associated antigenthat can stimulate autologous T-cell responses, and it is thereforeconsidered to be a potential immunotherapeutic target for thetreatment of various hematopoietic malignancies, including diffuselarge B-cell lymphoma.
Ghafouri-Fard, S., et al. Br. J. Dermatol. 162(4):772-779(2010)Ait-Tahar, K., et al. Br. J. Haematol. 146(4):396-407(2009)Sahota, S.S., et al. Blood 108(12):3953-3955(2006)Cooper, C.D., et al. Leukemia 20(12):2172-2174(2006)Guinn, B.A., et al. Biochem. Biophys. Res. Commun. 335(4):1293-1304(2005)
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