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BMS1L Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14692 |
|---|
| Gene ID | 9790 |
|---|---|
| Other Names | Ribosome biogenesis protein BMS1 homolog, Ribosome assembly protein BMS1 homolog, BMS1, BMS1L, KIAA0187 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1941a was selected from the N-term region of human BMS1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BMS1 (HGNC:23505) |
|---|---|
| Synonyms | BMS1L, KIAA0187 |
| Function | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. |
| Cellular Location | Nucleus, nucleolus |
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Provided below are standard protocols that you may find useful for product applications.
Background
BMS1L may act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus.
References
Crosier, M., et al., Genome Res. 12(1):67-80 (2002).
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