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GABRR1 Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24046 |
|---|---|
| Clone Names | 100318093 |
| Gene ID | 2569 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit rho-1, GABA(A) receptor subunit rho-1, GABA(C) receptor, GABRR1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GABRR1 (HGNC:4090) |
|---|---|
| Function | Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P56475}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in the retina (PubMed:1849271). Expressed in a lesser extent in brain, lung and thymus (PubMed:1849271). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GABA is the major inhibitory neurotransmitter in themammalian brain where it acts at GABA receptors, which areligand-gated chloride channels. GABRR1 is a member of the rhosubunit family.
References
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Green, E.K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :Reyes-Ruiz, J.M., et al. Biochim. Biophys. Acta 1798(5):1002-1007(2010)Xuei, X., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 418-427 (2010) :Kang, J.Q., et al. Trends Mol Med 15(9):430-438(2009)
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