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TXNRD3 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q86VQ6
Clone Names 100416186
Additional Information
Gene ID 114112
Other Names Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2, TXNRD3 {ECO:0000312|EMBL:AAH500321}
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNRD3 {ECO:0000312|EMBL:AAH50032.1}
Function Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum Note=Detected in cytoplasm and nucleus in late spermatids {ECO:0000250|UniProtKB:Q99MD6}
Research Areas
Citations (0)

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This gene encodes a member of the family of pyridinenucleotide oxidoreductases. This protein catalyzes the reduction ofthioredoxin, and is implicated in the defense against oxidativestress. It contains a selenocysteine (Sec) residue (which isessential for catalytic activity), encoded by a UGA codon, at thepenultimate C-terminal position. The 3' UTR of Sec-containing geneshave a common stem-loop structure, the sec insertion sequence(SECIS), which is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.


Gerashchenko, M.V., et al. J. Biol. Chem. 285(7):4595-4602(2010)Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)Harris, S.E., et al. BMC Genet. 8, 43 (2007) :Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)Sun, Q.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(7):3673-3678(2001)

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$ 277.78
Cat# BP19608c
Availability: 2 weeks
Bulk Size

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