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Dcr-1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P34529
Clone Names 6022602
Additional Information
Gene ID 176138
Other Names Endoribonuclease dcr-1, 3126-, dcr-1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1961b was selected from the C-term region of human Dcr-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name dcr-1 {ECO:0000303|PubMed:11641272, ECO:0000312|WormBase:K12H4.8}
Function Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307). Involved in innate immunity through its role in small RNA processing.
Research Areas
Citations (0)
citation

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Background

The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.

References

Duchaine TF, et al. 2006. Cell 124:343-354. Denli AM, et al. 2004. Nature 432:231-235. Tabara H, et al. 2002. Cell 109:861-871. Grishok A, et al. 2001. Cell 106:23-34. Knight SW, et al. 2001. Science 293:2269-2271.

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$ 277.78
Cat# BP1961b
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Availability: 2 weeks
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