|Other Names||Endoribonuclease dcr-1, 3126-, dcr-1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1961b was selected from the C-term region of human Dcr-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272).|
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Provided below are standard protocols that you may find useful for product applications.
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
Duchaine TF, et al. 2006. Cell 124:343-354. Denli AM, et al. 2004. Nature 432:231-235. Tabara H, et al. 2002. Cell 109:861-871. Grishok A, et al. 2001. Cell 106:23-34. Knight SW, et al. 2001. Science 293:2269-2271.
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