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(Mouse) Rybp Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q8CCI5
Additional Information
Gene ID 56353
Other Names RING1 and YY1-binding protein, Death effector domain-associated factor, DED-associated factor, Rybp, Dedaf
Target/Specificity The synthetic peptide sequence is selected from aa 131-145 of HUMAN Rybp
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Rybp
Synonyms Dedaf
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8N488}. Nucleus, nucleoplasm. Note=Primarily found in the nucleus Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.
Tissue Location Expressed in embryonic stem cells.
Research Areas
Citations (0)

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Background

Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity).

References

Carninci P.,et al.Science 309:1559-1563(2005).
Garcia E.,et al.EMBO J. 18:3404-3418(1999).
Danen-van Oorschot A.A.M.M.,et al.Cell Death Differ. 11:564-573(2004).
Pirity M.K.,et al.Mol. Cell. Biol. 25:7193-7202(2005).
Arrigoni R.,et al.FEBS Lett. 580:6233-6241(2006).

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$ 277.78
Cat# BP21378c
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