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PNMT Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11086 |
|---|
| Gene ID | 5409 |
|---|---|
| Other Names | Phenylethanolamine N-methyltransferase, PNMTase, Noradrenaline N-methyltransferase, PNMT, PENT |
| Target/Specificity | The synthetic peptide sequence is selected from aa 158-172 of HUMAN PNMT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PNMT |
|---|---|
| Synonyms | PENT |
| Function | Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L- methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617). Also methylates normetanephrine (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Converts noradrenaline to adrenaline.
References
Kaneda N.,et al.J. Biol. Chem. 263:7672-7677(1988).
Sasaoka T.,et al.Neurochem. Int. 15:555-565(1989).
Baetge E.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3648-3652(1988).
Martin J.L.,et al.Structure 9:977-985(2001).
Gee C.L.,et al.Biochemistry 44:16875-16885(2005).
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