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SYNJ1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O43426
Additional Information
Gene ID 8867
Other Names Synaptojanin-1, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 1, SYNJ1, KIAA0910
Target/Specificity The synthetic peptide sequence is selected from aa 1517-1531 of HUMAN SYNJ1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ1
Synonyms KIAA0910
Function Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Cellular Location Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}
Tissue Location Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals
Research Areas
Citations (0)

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Background

Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis.

References

Haffner C.,et al.FEBS Lett. 419:175-180(1997).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Hattori M.,et al.Nature 405:311-319(2000).
Cestra G.,et al.J. Biol. Chem. 274:32001-32007(1999).

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$ 277.78
Cat# BP21432b
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