YY1AP1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H869 |
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Gene ID | 55249 |
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Other Names | YY1-associated protein 1, Hepatocellular carcinoma susceptibility protein, Hepatocellular carcinoma-associated protein 2, YY1AP1, HCCA2, YY1AP |
Target/Specificity | The synthetic peptide sequence is selected from aa 437-448 of HUMAN YY1AP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | YY1AP1 (HGNC:30935) |
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Function | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). |
Cellular Location | Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus |
Tissue Location | Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Enhances transcription activation by YY1. May play a role in cell cycle regulation.
References
Wang Z.-X.,et al.Br. J. Cancer Suppl. 85:1162-1167(2001).
Wang C.-Y.,et al.J. Biol. Chem. 279:17750-17755(2004).
Zeng J.Z.,et al.Oncogene 21:4932-4943(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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