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(DANRE) waca Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q7ZUK7
Additional Information
Other Names WW domain-containing adapter protein with coiled-coil, waca, wac
Target/Specificity The synthetic peptide sequence is selected from aa 487-499 of HUMAN waca
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name waca
Synonyms wac
Function Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q9BTA9}. EMBL; AY576994; AAS92632.1; -; mRNA EMBL; BC048888; AAH48888.1; -; mRNA RefSeq; NP_955954.1; NM_199660.1 SMR; Q7ZUK7; - STRING; 7955.ENSDARP00000073355; - PaxDb; Q7ZUK7; - GeneID; 323904; - KEGG; dre:323904; - CTD; 323904; - ZFIN; ZDB-GENE-030131-2624; waca eggNOG; KOG0152; Eukaryota InParanoid; Q7ZUK7; - KO; K23884; - OrthoDB; 1111788at2759; - PhylomeDB; Q7ZUK7; - Reactome; R-DRE-8866654; E3 ubiquitin ligases ubiquitinate target proteins PRO; PR:Q7ZUK7; - Proteomes; UP000000437; Unplaced GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0003682; F:chromatin binding; ISS:UniProtKB GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB GO; GO:0044783; P:G1 DNA damage checkpoint; ISS:UniProtKB GO; GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; ISS:UniProtKB GO; GO:0010390; P:histone monoubiquitination; ISS:UniProtKB GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB CDD; cd00201; WW; 1 InterPro; IPR038867; WAC InterPro; IPR001202; WW_dom InterPro; IPR036020; WW_dom_sf PANTHER; PTHR15911; PTHR15911; 2 Pfam; PF00397; WW; 1 SMART; SM00456; WW; 1 SUPFAM; SSF51045; SSF51045; 1 PROSITE; PS01159; WW_DOMAIN_1; 1 PROSITE; PS50020; WW_DOMAIN_2; 1 2: Evidence at transcript level; Chromatin regulator; Coiled coil; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1..558 /note="WW domain-containing adapter protein with coiled- coil" /id="PRO_0000406981" DOMAIN 120..153 /note="WW" /evidence="ECO:0000255|PROSITE-ProRule:PRU00224" COILED 529..555 /evidence="ECO:0000255" COMPBIAS 191..231 /note="Ser-rich" COMPBIAS 325..430 /note="Ser-rich" CONFLICT 131 /note="S -> N (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 137 /note="Y -> F (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 153 /note="E -> K (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 220 /note="D -> N (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 259 /note="L -> P (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 312 /note="S -> T (in Ref. 1; AAS92632)" /evidence="ECO:0000305" CONFLICT 426 /note="Missing (in Ref. 1; AAS92632)" /evidence="ECO:0000305" SEQUENCE 558 AA; 60592 MW; 84F83593D163C7E9 CRC64; MVMYARKQPR LGDGCTDRRD SQPYQTLKYS SKSHPDHRHE KMRDSNDATP PCKMLRRSDS PDNKHMDNTG HGRAKAIHPH RGREREGGTS ISPQENSHNH SSLHSSNSHS NPNKSSDTPF EPADDWSEHI SSSGKKYYYN CRTEVSQWEK PKEWLEREQR QKEATKTAAV VNSFPKDRDY RREAMQATPA SYSSTKSSIA TEKPSSLTPS SSSAAVSGLD VPNSASSASG STVPVSPVMQ SPAPPTLLQD PSLLRQLLLA LQTALQLNNA SVDMAKINEV LTAAVTQASL QSILHKILTA GPSAFNITTL LSQATQLSNQ VAQQSSQSPM SLTSDASSPR SYVSPRISTP QTNTASLKPP LSTTPVSSQT KINAMTVKSS SLPPPSSQQP LSTEKHHDNG NSPRTLQRQS SQRSPSPGPN HMGSNSSSSS NNGGGGGGQG PGVVSGAMPP GSVPPGTAPG RATCSFTPTL AAHFNENLIK HVQGWPAEHV EKQASRLREE AHTMGSIYMS ENCTELKNLR SLVRVCEIQA TLREQRILFL RQQIKELEKL KNQNSFMV
Research Areas
Citations (0)

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Background

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.

References

Song H.-D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).

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$ 277.78
Cat# BP21526b
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