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NRGN Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92686 |
|---|
| Gene ID | 4900 |
|---|---|
| Other Names | Neurogranin, Ng, RC3, NEUG(55-78), NRGN |
| Target/Specificity | The synthetic peptide sequence is selected from aa 49-61 of HUMAN NRGN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NRGN |
|---|---|
| Function | Acts as a 'third messenger' substrate of protein kinase C- mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). |
| Tissue Location | In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
References
Mertsalov I.B.,et al.Bioorg. Khim. 22:366-369(1996).
Mertsalov I.B.,et al.Bioorg. Khim. 23:961-968(1997).
Martinez de Arrieta C.,et al.Genomics 41:243-249(1997).
Chang J.W.,et al.J. Neuropathol. Exp. Neurol. 56:1105-1118(1997).
Mertsalov I.B.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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