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SCAF8 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9UPN6
Additional Information
Gene ID 22828
Other Names Protein SCAF8, CDC5L complex-associated protein 7, RNA-binding motif protein 16, SR-related and CTD-associated factor 8, SCAF8, CCAP7, KIAA1116, RBM16
Target/Specificity The synthetic peptide sequence is selected from aa 520-534 of HUMAN SCAF8
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCAF8 {ECO:0000303|PubMed:9528809, ECO:0000312|HGNC:HGNC:20959}
Function Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839).
Cellular Location Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription
Research Areas
Citations (0)

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Background

May play a role in mRNA processing.

References

Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Patturajan M.,et al.Mol. Cell. Biol. 18:2406-2415(1998).
Ajuh P.,et al.EMBO J. 19:6569-6581(2000).

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$ 277.78
Cat# BP21643c
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