|Other Accession||Q2KHT6, Q9CPU7, Q1A730, Q91Z62|
|Other Names||F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx, FBXO32|
|Target/Specificity||The synthetic peptide sequence is selected from aa 17-29 of HUMAN FBXO32|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.|
|Cellular Location||Cytoplasm. Nucleus Note=Shuttles between cytoplasm and the nucleus|
|Tissue Location||Specifically expressed in cardiac and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Bodine S.C.,et al.Science 294:1704-1708(2001).
Sivertsen E.A.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Pescatori M.,et al.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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