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CPT1B Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92523 |
|---|---|
| Other Accession | NP_004368 |
| Clone Names | 3090208 |
| Gene ID | 1375 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT1B, KIAA1670 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2532b was selected from the C-term region of human CPT1B . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CPT1B |
|---|---|
| Synonyms | KIAA1670 |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Strong expression in heart and skeletal muscle. No expression in liver and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CPT1B is a member of the carnitine/choline acetyltransferase family, and is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria.
References
Dai, J., et al., Biochem. Biophys. Res. Commun. 301(3):758-763 (2003).van der Leij, F.R., et al., J. Biol. Chem. 277(30):26994-27005 (2002).Hirosawa, M., et al., DNA Res. 8(1):1-9 (2001).Yamazaki, N., et al., J. Biol. Chem. 275(41):31739-31746 (2000).Britton, C.H., et al., Genomics 40(1):209-211 (1997).
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