|Other Names||Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT1B, KIAA1670|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2540a was selected from the N-term region of human CPT1B . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein|
|Tissue Location||Strong expression in heart and skeletal muscle. No expression in liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
CPT1B is a member of the carnitine/choline acetyltransferase family, and is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria.
Dai, J., et al., Biochem. Biophys. Res. Commun. 301(3):758-763 (2003).van der Leij, F.R., et al., J. Biol. Chem. 277(30):26994-27005 (2002).Hirosawa, M., et al., DNA Res. 8(1):1-9 (2001).Yamazaki, N., et al., J. Biol. Chem. 275(41):31739-31746 (2000).Britton, C.H., et al., Genomics 40(1):209-211 (1997).
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