GGTLA1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P36269 |
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Gene ID | 2687 |
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Other Names | Gamma-glutamyltransferase 5, GGT 5, Gamma-glutamyl transpeptidase-related enzyme, GGT-rel, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase 5 heavy chain, Gamma-glutamyltransferase 5 light chain, GGT5, GGTLA1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GGT5 |
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Synonyms | GGTLA1 |
Function | Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). |
Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9Z2A9}; Single- pass type II membrane protein {ECO:0000250|UniProtKB:Q9Z2A9} |
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Provided below are standard protocols that you may find useful for product applications.
Background
GGTLA1 is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase.
References
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) Enoiu, M., et al. Free Radic. Biol. Med. 29(9):825-833(2000)
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