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ENY2 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9NPA8
Other Accession Q3KPT5, Q9JIX0, Q3ZBJ0, NP_064574.1
Additional Information
Gene ID 56943
Other Names Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}, Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046}, ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}
Target/Specificity The synthetic peptide sequence is selected from aa 17-31 of HUMAN ENY2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}
Function Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor- mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).
Cellular Location Nucleus, nucleoplasm {ECO:0000255|HAMAP- Rule:MF_03046, ECO:0000269|PubMed:22307388}. Note=Localization at the nuclear pore complex requires NUP153 and TPR
Research Areas
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References

Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)
Georgieva, S., et al. Mol. Cell. Biol. 21(15):5223-5231(2001)

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$ 277.78
Cat# BP5379a
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