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CLC3 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P51790
Other Accession P51792, O18894, P51791, O14918
Additional Information
Gene ID 1182
Other Names H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3
Target/Specificity The synthetic peptide sequence is selected from aa 677~691 of HUMAN CLCN3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCN3
Function [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874).
Cellular Location [Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P51792}; Multi-pass membrane protein. Note=Isoform 1 is localized mainly in late endosomes.
Tissue Location Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels Expressed in bronchus and colon (at protein level)
Research Areas
Citations (0)

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References

Salazar, G., et al., J. Biol. Chem. 279(24):25430-25439 (2004).
Gentzsch, M., et al., J. Biol. Chem. 278(8):6440-6449 (2003).
Olsen, M.L., et al., J. Neurosci. 23(13):5572-5582 (2003).
Hermoso, M., et al., J. Biol. Chem. 277(42):40066-40074 (2002).
Huang, P., et al., J. Biol. Chem. 276(23):20093-20100 (2001).

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$ 277.78
Cat# BP6329e
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