GRK6 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P43250 |
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Clone Names | 50908137 |
Gene ID | 2870 |
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Other Names | G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GRK6, GPRK6 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7132a was selected from the N-term region of human GRK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GRK6 |
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Synonyms | GPRK6 |
Function | Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Cellular Location | Membrane; Lipid-anchor. |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GRK6 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation.
References
Teli, T., et al., Mol. Endocrinol. 19(2):474-490 (2005).Hagen, S.A., et al., Anesthesiology 98(2):343-348 (2003).Miyagawa, Y., et al., Biochem. Biophys. Res. Commun. 300(3):669-673 (2003).Gaudreau, R., et al., J. Biol. Chem. 277(35):31567-31576 (2002).Willets, J.M., et al., J. Biol. Chem. 277(18):15523-15529 (2002).
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