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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PHB2 Blocking Peptide (Y248)   

PHB2 Blocking Peptide (Y248)

Synthetic peptide

Product Information
Primary Accession Q99623
Other Accession Q5XIH7, O35129, Q2HJ97, NP_009204
Additional Information
Gene ID 11331
Other Names Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH147661, ECO:0000312|HGNC:HGNC:30306}
Target/Specificity The synthetic peptide sequence is selected from aa 240-255 of HUMAN PHB2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
Cellular Location Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane [Isoform 2]: Mitochondrion inner membrane
Research Areas
Citations (0)

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PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.


Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007)
Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)

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$ 277.78
Cat# BP7270e
Availability: 2 weeks
Bulk Size

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