ARSB Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P15848 |
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Clone Names | 80411128 |
Gene ID | 411 |
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Other Names | Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7460c was selected from the Center region of human ARSB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARSB |
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Function | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). |
Cellular Location | Lysosome {ECO:0000250|UniProtKB:P50429}. Cell surface {ECO:0000250|UniProtKB:P50429} |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARSB belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B.
References
Peters C., Schmidt B.J. Biol. Chem. 265:3374-3381(1990)Modaressi S., Rupp K.Biol. Chem. Hoppe-Seyler 374:327-335(1993)Kobayashi T., Honke K.Biochim. Biophys. Acta 1159:243-247(1992)
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