Cyclin B1 Antibody (S128) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P14635 |
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Clone Names | 80104109 |
Gene ID | 891 |
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Other Names | G2/mitotic-specific cyclin-B1, CCNB1, CCNB |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7598a was selected from the S128 region of human Cyclin B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCNB1 |
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Synonyms | CCNB |
Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclin B1 is a regulatory protein involved in mitosis. It complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts of the cyclin B1 gene have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase.
References
Yoshida, T., et al., Ann. Oncol. 15(2):252-256 (2004).Chang, D.C., et al., J. Biol. Chem. 278(39):37865-37873 (2003).Sanchez, V., et al., J. Virol. 77(24):13214-13224 (2003).Li, J.Q., et al., Int. J. Oncol. 22(5):1101-1110 (2003).Porter, L.A., et al., Blood 101(5):1928-1933 (2003).
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