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CDC25C Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P30307 |
|---|
| Gene ID | 995 |
|---|---|
| Other Names | M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDC25C |
|---|---|
| Function | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). |
| Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDC25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest.
References
Varmeh,S., Mol. Cancer Ther. 7 (12), 3789-3799 (2008)Long,J.M., Cell Cycle 7 (19), 3062-3073 (2008)Bonnet,J., Cell Cycle 7 (13), 1991-1998 (2008)
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