SGK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HBY8 |
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Clone Names | 2032507 |
Gene ID | 10110 |
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Other Names | Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7947a was selected from the N-term region of human SGK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SGK2 |
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Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Highly expressed in liver, kidney and pancreas, and at lower levels in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
References
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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