CNTN6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UQ52 |
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Clone Names | 90904117 |
Gene ID | 27255 |
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Other Names | Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8561c was selected from the Center region of human CNTN6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CNTN6 |
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Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
Tissue Location | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord |
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Provided below are standard protocols that you may find useful for product applications.
Background
CNTN6 is a member of the immunoglobulin superfamily. It is a cosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
References
Manderson,E.N., et.al., Int. J. Gynecol. Cancer 19 (4), 513-525 (2009)
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