|Other Names||Protein Mpv17, MPV17|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8749a was selected from the N-term region of human MPV17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
MPV17 is a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species.
Iida,R., et.al., J. Biol. Chem. 278 (8), 6301-6306 (2003)Karasawa,M., et.al., Hum. Mol. Genet. 2 (11), 1829-1834 (1993)
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