|Other Names||Inositol-pentakisphosphate 2-kinase, IPK1 homolog, Inositol-1, 6-pentakisphosphate 2-kinase, Ins(1, 6)P5 2-kinase, InsP5 2-kinase, IPPK, C9orf12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9236c was selected from the Center region of human IPPK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Ubiquitously expressed, with high expression in heart, brain, testis and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
IPPK belongs to the IPK1 type 2 family. It phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). IPPK is ubiquitous, with high expression in heart, brain, testis and placenta.
Verbsky,J. et.al, Nature 429 (6990), 369-374 (2004)Verbsky,J.W., et.al, J. Biol. Chem. 277 (35), 31857-31862 (2002)
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