GABRD Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14764 |
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Clone Names | 91009150 |
Gene ID | 2563 |
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Other Names | Gamma-aminobutyric acid receptor subunit delta, GABA(A) receptor subunit delta, GABRD |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9299c was selected from the Center region of human GABRD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GABRD |
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Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
GABRD is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This protein encodes the delta subunit.
References
Gratacos,M., et.al, Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)Maldonado-Aviles,J.G., et.al, Am J Psychiatry 166 (4), 450-459 (2009)Tabakoff,B., et.al, BMC Biol. 7, 70 (2009)
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