|Other Names||Centromere protein V, CENP-V, Nuclear protein p30, Proline-rich protein 6, CENPV, PRR6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.|
|Cellular Location||Chromosome, centromere, kinetochore. Nucleus Cytoplasm, cytoskeleton, spindle Note=Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885)|
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Provided below are standard protocols that you may find useful for product applications.
CENPV is required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Tadeu, A.M., et al. EMBO J. 27(19):2510-2522(2008)Cronshaw, J.M., et al. J. Cell Biol. 158(5):915-927(2002)
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