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ERF3B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IYD1 |
|---|
| Gene ID | 23708 |
|---|---|
| Other Names | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B, Eukaryotic peptide chain release factor subunit 3b, eRF3b, G1 to S phase transition protein 2 homolog, GSPT2, ERF3B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GSPT2 |
|---|---|
| Synonyms | ERF3B |
| Function | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:11524954, PubMed:17562865). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:15987998). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:15987998). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in IUCC stage II colorectal cancer (CRC). |
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Provided below are standard protocols that you may find useful for product applications.
Background
ERF3B encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.
References
Cheng, Z., et al. Genes Dev. 23(9):1106-1118(2009)Zhouravleva, G., et al. IUBMB Life 58(4):199-202(2006)Chauvin, C., et al. Mol. Cell. Biol. 25(14):5801-5811(2005)Hoshino, S., et al. J. Biol. Chem. 274(24):16677-16680(1999)Hansen, L.L., et al. Cytogenet. Cell Genet. 86 (3-4), 250-251 (1999)
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