IGF-BP5, human recombinant protein
Insulin-like Growth Factor-Binding Protein5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24593 |
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Calculated MW | 28. 6 kDa |
Gene ID | 3488 |
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Gene Symbol | IBP5 |
Other Names | Insulin-like Growth Factor-Binding Protein5 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥98% |
Assay2&Purity2 | HPLC; ≥98% |
Recombinant | Yes |
Results | <0.3 mg/ml |
Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use. |
Format | Lyophilized protein |
Storage | -20°C; Sterile filtered and lyophilized from 10 mM Sodium Citrate solution, pH 3.0. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by Vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
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