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MART-1/Melan-A, mouse recombinant protein
Melanoma antigen recognized by T-cells 1, Antigen LB39-AA, Antigen SK29-AA, MART-1, Melan-A
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q2TA50 |
|---|---|
| Calculated MW | 17.6 kDa |
| Gene ID | 77836 |
|---|---|
| Gene Symbol | Melan-A |
| Other Names | Melanoma antigen recognized by T-cells 1, Antigen LB39-AA, Antigen SK29-AA, MART-1, Melan-A |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | N/A; |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Target/Specificity | MART-1/Melan-A |
| Format | Liquid |
| Storage | -20°C; MART-1/Melan-A protein is in 50 mM Tris, pH 7.5, 100 mM NaCl, 20 mM β-mercaptoethanol, and 20%Glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is expressed by a large proportion of melanoma tumors, both melanotic and amelanotic and by melanoma cell lines. It is present in melanocytes of normal skin and retina, nevi and in more than 85% of melanomas. Melan-A/MART-1 is not expressed by non-melanoma malignancies. It is recognized by autologous cytotoxic T lymphocytes. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Mouse MART-1 is purified by proprietary chromatographic techniques.
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